Searchable abstracts of presentations at key conferences on calcified tissues

ba0006oc3 | (1) | ICCBH2017

Principal component-derived bone density phenotypes and genetic regulation of the pediatric skeleton

Mitchell Jonathan , Chesi Alessandra , McCormack Shana , Cousminer Diana , Kalkwarf Heidi , Lappe Joan , Gilsanz Vicente , Oberfield Sharon , Shepherd John , Kelly Andrea , Zemel Babette , Grant Struan

Objectives: To determine if genetic variants associated with principal component-derived areal bone mineral density (aBMD) loading scores.Methods: Our sample comprised 1,293 children of European ancestry enrolled in the longitudinal Bone Mineral Density in Childhood Study (52% female). The participants completed up to 7 annual study visits. From dual energy X-ray absorptiometry scans, sex and age-specific aBMD Z-scores were calculated for total hip, femo...

ba0007p94 | (1) | ICCBH2019

Characteristics of ultradistal radius bone density during childhood: results from the Bone Mineral Density in Childhood Study

Kindler Joseph , Mitchell Jonathan , McCormack Shana , Cousminer Diana , Chesi Alessandra , Kelly Andrea , Lappe Joan , Gilsanz Vicente , Oberfield Sharon , Shepherd John , Winer Karen , Kalkwarf Heidi , Grant Struan , Zemel Babette

Objective: The forearm is a common fracture site during childhood, but DXA pediatric reference data for areal bone mineral density (aBMD) at the ultradistal (UD) radius are lacking. The objective of this study was to first, develop age-, sex-, and ancestry-specific reference data for UD radius aBMD; second, assess the relationship between UD radius aBMD and a) other DXA aBMD measures and b) radius bone volumetric density and geometry by pQCT; and third, examine the tracking of...